Gregor Bein Selected Research

human ITGB3 protein (HPA-1a)

11/2019	Current Anti-HPA-1a Standard Antibodies React with the β3 Integrin Subunit but not with αIIbβ3 and αvβ3 Complexes.
7/2013	Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti-HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia.
11/2011	Low-avidity anti-HPA-1a alloantibodies are capable of antigen-positive platelet destruction in the NOD/SCID mouse model of alloimmune thrombocytopenia.
5/2009	Low-avidity HPA-1a alloantibodies in severe neonatal alloimmune thrombocytopenia are detectable with surface plasmon resonance technology.
2/2009	Blockade of maternal anti-HPA-1a-mediated platelet clearance by an HPA-1a epitope-specific F(ab') in an in vivo mouse model of alloimmune thrombocytopenia.
8/2007	Rapid detection of HPA-1 alloantibodies by platelet antigens immobilized onto microbeads.

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Gregor Bein Research Topics

Disease

19	Neonatal Alloimmune Thrombocytopenia 01/2022 - 02/2009
10	Hemorrhage 01/2022 - 08/2011
9	Thrombocytopenia (Thrombopenia) 01/2022 - 02/2009
6	Infections 10/2021 - 04/2005
5	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 01/2019 - 02/2012
5	Graft vs Host Disease (Graft-Versus-Host Disease) 11/2018 - 01/2009
4	Transfusion-Related Acute Lung Injury 10/2021 - 10/2005
4	Body Weight (Weight, Body) 11/2018 - 11/2009
3	Neutropenia 01/2021 - 11/2006
3	Neoplasms (Cancer) 01/2019 - 01/2009
3	Transfusion Reaction 01/2016 - 08/2007
2	Inflammation (Inflammations) 10/2021 - 10/2019
2	Thrombasthenia (Glanzmann Thrombasthenia) 01/2021 - 01/2016
2	Pneumonia (Pneumonitis) 10/2019 - 01/2012
2	Wounds and Injuries (Trauma) 01/2010 - 05/2008
2	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2010 - 05/2008
2	Lung Diseases (Lung Disease) 01/2009 - 04/2005
2	Penile Induration (Peyronie's Disease) 10/2003 - 01/2003
1	Lung Injury 10/2021
1	Glomerulonephritis 01/2021
1	Periodontitis 12/2020
1	Intellectual Disability (Idiocy) 12/2020
1	Skin Diseases (Skin Disease) 12/2020
1	Lymphopenia (Lymphocytopenia) 08/2020
1	Anemia 02/2020
1	Birth Weight (Birth Weights) 01/2020
1	Bacterial Infections (Bacterial Infection) 10/2019
1	Chickenpox 01/2019
1	Bronchiolitis Obliterans Syndrome 11/2018
1	Malaria 01/2018
1	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 03/2015
1	Bacterial Pneumonia 09/2013
1	Basal Cell Carcinoma (Rodent Ulcer) 01/2012
1	Warts (Wart) 01/2012
1	Critical Illness (Critically Ill) 11/2009
1	Respiratory Insufficiency (Respiratory Failure) 01/2009
1	Lymphoma (Lymphomas) 01/2009
1	Hematologic Neoplasms (Hematological Malignancy) 01/2009
1	Primary Immunodeficiency Diseases 01/2009
1	Neonatal Hyperbilirubinemia 03/2007
1	Gilbert Disease 03/2007
1	Autoimmune Hemolytic Anemia (Cold Agglutinin Disease) 03/2007
1	Hyperbilirubinemia 03/2007
1	Mycoses (Diseases, Fungus) 11/2006

Drug/Important Bio-Agent (IBA)

17	AntibodiesIBA 01/2022 - 08/2004
11	IsoantibodiesIBA 01/2021 - 05/2009
8	Human Platelet AntigensIBA 01/2020 - 05/2009
7	AntigensIBA 10/2021 - 10/2003
6	human ITGB3 protein (HPA-1a)IBA 11/2019 - 08/2007
5	AutoantibodiesIBA 01/2021 - 02/2012
4	Immunoglobulin G (IgG)IBA 02/2020 - 04/2011
4	Inosine Triphosphate (ITP)IBA 01/2019 - 02/2012
4	Glycoproteins (Glycoprotein)IBA 01/2019 - 08/2011
3	CytokinesIBA 10/2019 - 01/2003
3	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 01/2009 - 04/2005
2	Proteins (Proteins, Gene)FDA Link 10/2021 - 10/2021
2	IntegrinsIBA 01/2021 - 01/2016
2	Isoantigens (Alloantigen)IBA 02/2020 - 02/2009
2	HLA Antigens (Human Leukocyte Antigens)IBA 01/2020 - 01/2011
2	Antiviral Agents (Antivirals)IBA 10/2019 - 08/2006
2	Pharmaceutical PreparationsIBA 01/2019 - 08/2004
2	LigandsIBA 01/2018 - 01/2012
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 06/2015 - 11/2006
2	Heparin (Liquaemin)FDA LinkGeneric 12/2011 - 04/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2010 - 05/2008
1	Fibrinogen (Factor I)FDA Link 05/2021
1	Factor XIII (Coagulation Factor XIII)IBA 05/2021
1	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2021
1	FucoseIBA 12/2020
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 08/2020
1	Intravenous Immunoglobulins (IVIG)FDA Link 01/2020
1	Piperacillin FDA LinkGeneric 01/2020
1	Immunologic Factors (Immunomodulators)IBA 10/2019
1	Adenosine (Adenocard)FDA LinkGeneric 01/2019
1	HLA-DRB3 Chains (HLA DRB3)IBA 01/2017
1	Interferon-alpha (Interferon Alfa)IBA 09/2013
1	Sialic Acid Binding Immunoglobulin-like LectinsIBA 09/2013
1	Monoclonal AntibodiesIBA 07/2013
1	Interleukin-10 (Interleukin 10)IBA 01/2012
1	Imiquimod (Aldara)FDA LinkGeneric 01/2012
1	Platelet Membrane Glycoprotein IIbIBA 11/2011
1	Platelet Factor 4IBA 04/2011
1	Biological ProductsIBA 01/2011
1	SteroidsIBA 11/2009
1	EpitopesIBA 02/2009
1	BilirubinIBA 03/2007
1	UridineIBA 03/2007
1	Heme Oxygenase-1IBA 03/2007

Therapy/Procedure

4	Therapeutics 12/2020 - 11/2007
4	Blood Component Removal (Apheresis) 11/2018 - 11/2009
4	Photopheresis 11/2018 - 11/2009
3	Contraindications 11/2018 - 11/2009
2	Blood Transfusion (Blood Transfusions) 10/2021 - 01/2009
1	Platelet Transfusion (Blood Platelet Transfusions) 01/2021
1	General Anesthesia 12/2020
1	Immunotherapy 03/2015
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2009
1	Organ Transplantation 01/2009
1	Stem Cell Transplantation 01/2009
1	Drug Therapy (Chemotherapy) 11/2006